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SAN FRANCISCO Uomo Nike Air Max 97 2017 Retro Argento Scontate Italia , June 3 (Xinhua) -- New research suggests the bacteria that cause tuberculosis (TB) alter their metabolism to combat exposure to antimicrobials, and new drugs could neutralize the metabolic "escape pathways" to shorten the duration of therapy.


The findings, published recently in Antimicrobial Agents and Chemotherapy, are hailed as important because the respiratory disease kills nearly 2 million people a year worldwide, and its long treatment regimen leads to poor compliance and Nike Air Max Plus TN Ultra Bianche Scontate Italia , in turn, drug-resistant germs.


About one-third of the global population is infected with Mycobacterium tuberculosis, or Mtb, though only a small percentage will develop TB.


For those who do, treatment is basically the same now as it was a half-century ago: taking a combination of drugs for six months Uomo Nike Air Max TN Marina Scontate Italia , because the germs do not die easily.


Luiz Bermudez and collaborators at the veterinary college of Oregon State University (OSU), as well as researchers at OSU's colleges of science and pharmacy and Oregon Health & Science University, took a biology-driven approach to learn how Mtb prolongs survival following exposure to bactericidal concentrations of antimicrobials.


In an effort to investigate how the bacteria reacted to each class of anti-TB drug with the goal of making headway toward developing a more-reasoned combination therapy, the researchers studied the proteomic responses of the bacteria to five compounds, namely isoniazid Nike Air Max Flair Bianche Scontate Italia , rifampicin, moxifloxacin, mefloquine and bedaquiline, and discovered escape pathways and enzymes associated with changes in metabolic state.


"When we looked at the enzymes carefully, we realized the enzymes being synthesized by the bacteria were enzymes connecting several different metabolic pathways Nike Air Max 90 Ultra 2.0 Essential Bianche Scontate Italia ," Bermudez said.


"Then we came up with the idea that maybe what the bacteria were trying to do, in the presence of a bactericidal compound that was threatening their way of living, was use other ways to survive. One of the things we saw, for example, was a shift to an anaerobic metabolism Donne Nike Air Max 90 Ultra Essential Rosa Scontate Italia , which makes a lot of drugs inactive and incapable of killing bacteria."


Using a combination of drugs to treat TB arose as an attempt to prevent antibiotic resistance, he noted.


"But the antibiotics used were never a rational combination of drugs and in some cases they could antagonize each other," he was quoted as saying in a news release from OSU.


"If we can use another compound that inhibits bacteria from shifting metabolic pathways, then we get a more reliable and desirable synergy of therapy. That might have a significant impact on reducing the time needed for therapy and improving compliance and, consequently Donne Nike Air Max 90 Ultra 2.0 Essential Rosa Scontate Italia , reducing the emergence of resistance."


"The gene inactivation of some of these enzymes results in improved drug efficacy against Mtb," he said. "The identified proteins may provide powerful targets for development of synergistic drugs aimed to accelerate bacterial killing."


The researchers said that anyone who's ever had trouble sticking with a 10-day antibiotic regimen for an ear infection can understand the hurdles in taking multiple medicines for a couple of dozen weeks, especially given the numerous side effects of the TB drugs.


Another compliance issue is that TB is particularly prevalent in impoverished countries in which patients often live great distances from pharmacies and other medical facilities.


"Because of problems with compliance, you have resistance becoming more and more of an issue," said Bermudez.


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LONDON, Sept. 28 (Xinhua) -- The delegation of China Foundation for Human Rights Development(CFHRD)wrapped up its three-day visit to Britain on Thursday.


The delegation, headed by Huang Mengfu, chairman of the CFHRD, visited British institutions including the British Parliament Uomo Nike Air Max 90 Ultra Moire Bianche Scontate Italia , the Bar Council and the Asia House, exchanging views with members of Parliament,experts and scholars on issues such as human rights protection and legal construction.


Huang said that over the past five years, the basic rights of the Chinese people have been further protected as the economic, legal and democratic construction in China keep advancing.


He stressed that as the world's largest developing country Uomo Nike Air Max 90 Ultra Moire Nere Scontate Italia , China should uphold development as its priority.


"The right to life and right to development are primary human rights for China," he said.


Huang said that he believes it is normal for countries to have different views on human rights since they have different history and cultural inheritance, social system as well as development level.


The British side said it is very necessary for the two countries to have communication and exchanges on issues concerning human rights, urging strengthened bilateral exchanges on the grassroots level as well as the government level in the future.


The delegation had visited Italy and the Czech Republic.




NEW YORK， Aug. 30 (Xinhua) -- Top seeded Serena Williams swept past unseeded Russian Ekaterina Makarova 6-3， 6-3 in the first round of the US Open here on Tuesday.


Williams enjoyed the 63-minute victory by hitting 12 aces， with only one double-fault. "I got off to a fast start， and I didn't want to start out slow. That's all I could do today，" said Williams， who played just three singles matches since the Wimbledon. Wholesale Jerseys Cheap Wholesale Sports Jerseys Wholesale Hats Cheap Hats Cheap Hats Cheap College Shirts Cheap Soccer Shirts Cheap Adidas NHL Hoddies Cheap Nike NFL Hoddies Cheap Nike NBA Hats